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innovex biosciences(innovexbio)产品介绍

日期:2021-07-27浏览:166次

innovex biosciences(innovexbio)产品介绍
Fc Receptor Blocker – (4x Concentrate)

Fc 受体 (FcR) 是分子量约为 50-70 kD 的糖蛋白。他们被广泛表达整个免益细胞。 Fc 受体存在于白细胞上,例如单核细胞、组织巨噬细胞、B 细胞、粒细胞(嗜酸性粒细胞、嗜碱性粒细胞、中性粒细胞)、NK 细胞和一些 T 细胞。 Fc受体也存在于肥大细胞上,滤泡树突细胞、上皮细胞、内皮细胞、肝细胞和朗格汉斯细胞等。有几个

Fc 受体 (FcR) 的类型,根据它们识别的抗体进行分类。有那些伟大的对单体 IgG 抗体的 Fc 区有亲和力,称为 Fc-Gamma 受体,与 IgA 抗体结合的称为 Fc-Gamma 受体称为 Fc-α 受体和结合 IgE 抗体的那些称为 Fc-ε 受体。

IHC、ICC、免疫荧光 (IF) 和流式细胞术等检测中的非特异性 Fc 受体染色可能是由于一抗和/或二抗或免疫球蛋白同种型的 Fc 区与抗体 Fc 受体的结合细胞。消除 Fc 受体染色在 IHC、ICC、IF 和流式细胞术检测中是可取的,目的是为了准确

数据评估。

For IHC, ICC, IF testing: The binding of the Fc region of primary and/or secondary antibody and immunoglobulin

isotypes to the Fc receptors present on cells/tissues give rise to non-specific Fc receptor staining. Specimens rich in Fc

receptors include spleen, lymphoid tissues, lymphomas, tonsil, lymph nodes, bone marrow, blood smears and liver. Others

include tissues and cell preps intended for staining for CD markers; Immunoglobulins (Igs), Kappa and Lambda and tumor

cell lines that express Fc receptors.

To avoid Fc receptor staining; tissue sections and cell preparations are incubated with Innovex Fc Blocker for a short period

prior to application of primary antibody or immunoglobulin isotypes (See instruction section of this data sheet).

For Flow cytometry assays: Fc receptors are present on leukocytes (white blood cells), many cell lines as well as other

cell types in both human and animal cells/tissues. Fc receptors gives rise to non-specific Fc receptor-staining in flow

cytometry assays by binding of Fc region of antibodies and isotype controls to Fc receptors of the cells. Non-specific Fc

receptors staining can be eliminated by incubating cells with INNOVEX Fc Receptor Blocker for a variety of Flow cytometry

assays such as CD phenotyping, leukemia typing and cell line studies. (See instruction section of this data sheet).

PRODUCT DESCRIPTION

Innovex Fc Receptor Blocker is a UNIVERSAL Fc Blocker applicable to blocking all types of Fc receptors such as Fc-gamma receptors of type I,

II and III; Fc -epsilon receptors type I and II; Fc –alpha receptors, Fcα/ µR and FcRn.

Innovex Fc Blocker does NOT contain antibodies, Immunoglobulins or immunoglobulin fragments.

INNOVEX Fc Blocker can be universally applied to block all types of Fc receptors in all-species including human, mouse

and all-animals This Universal Fc Block can be used in a variety of Immunoassays such as IHC, ICC, Immunofluorescence

and Flow cytometry. INNOVEX UNIVERSAL Fc BLOCK is suitable for blocking Fc receptors in frozen and paraffin tissue

sections and cyto preps of human and all-animal species.

INNOVEX Fc Blocker is also commonly used for eliminating background staining in brain cells/tissues.


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